Osteoporosis was a degenerative bone disease characterized by decreased bone mass,decreased bone mineral density,bone microstructure destruction and increased bone brittleness.Recent studies showed immune system played an important regulative role in the development of osteoporosis.In the present review,on the basis of illustrating the relationship between the immune response and osteoporosis,we focus on summarization of several immune inflammatory factors,such as TNF-α,TGF-β and ILs in the development of osteoporosis,and further summarize the possible role of immune regulation in the treatment of osteoporosis.