【摘 要】
：
Objective To investigate the effects of O-carboxymethyl chitosan (O-CMC) multi-hemostatic Sponge on the immobilization of thrombin.Methods The formulation of O-CMC multi-hemostatic Sponge was optimize
【机 构】
：
Department of Pharmacy, Wuhan General Hospital of Guangzhou Military Command, Hubei Wuhan, 430070, C
【出 处】
：
2013年中国药物制剂大会——中国药学会药剂专业委员会2013年学术年会暨国际控释协会中国分会2013年学术年会
论文部分内容阅读
Objective To investigate the effects of O-carboxymethyl chitosan (O-CMC) multi-hemostatic Sponge on the immobilization of thrombin.Methods The formulation of O-CMC multi-hemostatic Sponge was optimized by using central composite design-response surface methodology (CCD-RSM), in which the O-CMC, glutaraldehyde and thrombin was used as enzyme immobilization carrier, crosslink agent and coagulant, respectively.The crosslinked conditions of thrombin were studied by determined the enzymatic activity yield.Results The optimized concentrations of O-CMC, thrombin and glutaraldehyde were 2.49 %, 49.87 IU/mL, 0.49%, respectively.Conclusion O-CMC multi-hemostatic Sponge has the positive immobilization effect on thrombin.
其他文献
Two essential characteristics of therapeutic nanocarriers are their rapid uptake into, and their specific recognition by tumor cells.Here we aim to develop a facile dual-ligand modification strategy t
The solubility of drug molecules can often be improved through preparation and delivery of cyclodextrin (CD) inclusion complexes.The aim of the study was to investigate the potential of inclusion comp
In order to enhance the dissolution properties of poorly water-soluble drug-Ibuprofen, solid dispersion was prepared using supercritical fluid technology.Aerosil 200 was used as the carrier to prepare
OBJECTIVE: To establish a UV method for the dissolution determination of voriconazole capsules and a simple and rapid LC-MS method for the determining the voriconazole concentration in human plasma af
Objective: At present, one of the bottlenecks in gene therapy is the low gene transfection efficiency.Studies have found that, under the effect of ultrasonic, ultrasound micro-bubble generated a cavit
In this study, our aim was to develop an injectable drug reservoir to provide sustained, pH-sensitive curcumin-loaded ketal based chitosan micelles, mPEG-Chitosan-Ketal (PCK).A novel water-soluble chi