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Transcription initiation factor ⅡB (TFⅡB) is a general transcription initiation factor that plays a pivotal role in the response to transcriptional activator proteins.Previous reports have shown that TFⅡB have been implicated in the pathogenesis of various experimental central nervous system diseases.However, its distribution and function in the retina remain unclear.In the present study, we investigated the spatiotemporal expression of TFⅡB in a lightinduced retinal damage model.Western blotting analysis showed TFⅡB level signi cantly improved 3 days after injury, and then declined during the following days.The association of TFⅡB and retinal ganglion cells (RGCs) was detected by immunofluorescence double staining.The injury-induced expression of TFⅡB was physically coexisted with active caspase-3 and TUNEL (apoptotic markers).Spatiotemporal changes of TFⅡB expression suggest that this protein may play a role in the degenerative process of RGCs by light-induced damage in the retina.