Oxidative stress is an important factor triggering the aggregation of cataract-causing □-crystallin

来源 :中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 | 被引量 : 0次 | 上传用户:rifcumtd111
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Crystallins are the major structural proteins in mammalian lens and their stability is essentialfor the lens to maintain transparency throughout one individuals lifespan.In normallens, the crystallins are protected from oxidization by the high concentration of glutathione(GSH) within the lens.While in the case of aging cataract lens, the GSH concentrationis decreased and proteins including crystallins undergo oxidization and lose the abilityto maintain stable and soluble.
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