【摘 要】
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Background Multidrug resistance (MDR) is most common reason related to the failure of chemotherapy in cancer.The multidrug resistance includes intrinsic multidrug resistance and acquired multidrug res
【机 构】
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Department of Pharmaceutics,School of Pharmacy,Harbin Medical University,Harbin,150086,P.R.China
【出 处】
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2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会
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Background Multidrug resistance (MDR) is most common reason related to the failure of chemotherapy in cancer.The multidrug resistance includes intrinsic multidrug resistance and acquired multidrug resistance.The acquired resistance to cancer may come from a drug stimulus, leading to the overexpression of ATP-binding cassette (ABC) transporters such as P-glycoprotein (P-gp), and subsequent efflux of anticancer drugs from within cancer cells.Intrinsic resistance is mainly caused by defects in apoptosis, which is associated with mitochondria.
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