【摘 要】
：
N-α-acetyltransferase 10 protein, Naal0p, is an N-acetyltransferase known to be involved in cell cycle control.We found that Naal 0p was expressed lower in
【机 构】
：
GraduateInstituteofToxicology,NationalTaiwanUniversityCollegeofMedicineTaiwan
【出 处】
：
BITs 3rd Annual World Cancer Congress-2012(2012第五届世界癌症大会)
论文部分内容阅读
N-α-acetyltransferase 10 protein, Naal0p, is an N-acetyltransferase known to be involved in cell cycle control.We found that Naal 0p was expressed lower in varieties of malignancies with lymph node metastasis compared with nonlymph node metastasis.Higher Naa 10p expression correlates the survival of lung cancer patients.Naa 10p significantly suppressed migration, tumor growth, and metastasis independent of its enzymatic activity.Instead, Naal0p binds to the GIT-binding domain of PIX, thereby preventing the formation of the GIT-PIX-Paxillin complex, resulting in reduced intrinsic Cdc42/Rac 1 activity and decreased cell migration.Forced expression of PIX in Naal 0-transfected tumor cells restored the migration and metastasis ability.We suggest that Naa 1 0p functions as a tumor metastasis suppressor by disrupting the migratory complex, PIX-GIT-Paxillin, in cancer cells.
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