Synthesis and Anti-HIV Activity Evaluation of 1,2,3-Thiadiazol-4-ylthioacetamides Derivatives

来源 :第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 | 被引量 : 0次 | 上传用户：shaodongjia1668

【摘要】

：

【作者】

：

Peng Zhan Xiaofei Jiang Wenmin Chen Xuwang Chen Ye Tian Xinyong Liu Christophe Pannecouque Erik De Clercq

【机构】

：

Department of Medicinal Chemistry,Key Laboratory of Chemical Biology of Natural Products(Ministry of

【出处】

：

第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会

【发表日期】

：

2012年8期

【关键词】

：

Thiadiazolethioacetanilides Synthesis Antiviral activity HIV-1

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　　In order to expand the structure-activity relationship(SAR) studies on arylazolylthioacetanilide NNRTIs [1-14],based on the structure-based bioisosterism principle,a series of novel 2-(5-(naphthalen-1-yl)-1,2,3-thiadiazol-4-ylthio)-N-acetamides derivatives were designed,synthesized and evaluated for their anti-HIV activities in MT-4 cells.

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Synthesis and Anti-HIV Activity Evaluation of 1,2,3-Thiadiazol-4-ylthioacetamides Derivatives

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