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目的探讨鼻塞持续气道正压(CPAP)对儿童高原性心脏病的治疗作用,观察其在治疗儿童高原性心脏病中的临床效果。方法将41例患儿分为对照组和治疗组。对照组给予强心、利尿、ACEI、吸氧(流量2～5L/min)等常规治疗。治疗组在常规治疗基础上给予无创机械通气,治疗14d后观察两组右室射血分数(REF),右心房收缩波(As)、肺动脉压力,心胸比例,RPEP/RAT。结果两组右室射血分数(REF),右心房收缩波(As)、肺动脉压力,RPEP/RAT,心胸比例。治疗后与治疗前相比有显著改善(P﹤0.05),治疗后治疗组与对照组组间比较差异有统计学意义(P﹤0.05)。结论儿童高原性心脏病患者在常规治疗基础上给予无创机械通气有利于改善右心室收缩、舒张功能、肺动脉压力及心胸比例,是治疗高原性心脏病重要手段之一。
Objective To investigate the therapeutic effect of nasal continuous positive airway pressure (CPAP) on children with high altitude heart disease and to observe its clinical effect in treating children with high altitude heart disease. Methods 41 cases were divided into control group and treatment group. The control group was given cardiac, diuretic, ACEI, oxygen (flow 2 ~ 5L / min) and other conventional treatment. The treatment group was given non-invasive mechanical ventilation on the basis of routine treatment. After 14 days of treatment, the right ventricular ejection fraction (REF), right atrial systolic wave (As), pulmonary artery pressure, cardiothoracic ratio, RPEP / RAT were observed. Results The two groups of right ventricular ejection fraction (REF), right atrial contraction wave (As), pulmonary artery pressure, RPEP / RAT, heart and chest ratio. After treatment, there was a significant improvement compared with that before treatment (P <0.05). There was significant difference between the treatment group and the control group after treatment (P <0.05). Conclusions Non-invasive mechanical ventilation on the basis of routine treatment is beneficial to improve the right ventricular systolic and diastolic function, pulmonary artery pressure and cardiothoracic ratio in children with CPAP. It is one of the important means to treat CPHD.