【摘 要】
:
HSP90(heat shock protein 90) is a molecular chaperone to assist other proteins folding properly in response to cell stress,and is one of the most abundant proteins expressed in cells.Recent studies we
【机 构】
:
State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Scienc
【出 处】
:
第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
HSP90(heat shock protein 90) is a molecular chaperone to assist other proteins folding properly in response to cell stress,and is one of the most abundant proteins expressed in cells.Recent studies were shown that a number of proteins involved in tumor growth are clients of HSP90.Inhibition of HSP90s activity was associated with degradation of many onco-proteins,and affected several signaling pathway,such EGFR,PI3K-AKT,JAK-STAT pathways.Therefore,HSP90 was considered to be a good anti-cancer drug target.
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