Background: Epithelial cell adhesion molecule (EpCAM) is overexpressed abnormally in nearly all adenocarcinomas including colon cancer, gastric cancer, breast cancer and so on.The highest expression levels of EpCAM on gastrointestinal adenocareinomas are more than 95％.EpCAM is closely related to the proliferation of cancer cells and the prognosis of the tumor.In recent years, EpCAM has been regarded as the new target of immunotherapy of tumor.Culturing EpCAM specific effectors is used to generate new effectors that with better specific killing effective.