【摘 要】
：
Evodiamine and Berberine, natural compounds isolated from the plant Evodiae fructus and Berberisamurensisanrespectively, have been found to be potent antitumor agents.However,the synergistic anti-canc
【机 构】
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Research Center for Traditional Chinese Medicine Complexity System,Shanghai University of Traditiona
【出 处】
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全国中药药理学会联合会学术交流大会
论文部分内容阅读
Evodiamine and Berberine, natural compounds isolated from the plant Evodiae fructus and Berberisamurensisanrespectively, have been found to be potent antitumor agents.However,the synergistic anti-cancer effect and the precise mechanism of combination of evodiamine and berberine on human breast cancer remain unclear.MicroRNAs (miRNAs) are small noncoding RNA moleculars that their aberrant expressions correlate with various cancers.MiR-185 has been validated a novel tumor suppressor in human cancers.In this study, we demonstrated that the combination of evodiamine and berberine not only possesses the synergistic effect of growth inhibition, cell cycle arrest and apoptosis induction, but also up-regulates miR-185 expression in human breast cancer MCF-7 cells, compared to evodiamine or berberine treatment alone.
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