【摘 要】
：
Cancer results from the interaction of multiple aberrations including activation of dominant oncogenes and upregulation of signal transduetion pathways.An important example of such genes is Vav 1, a c
【机 构】
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The Hebrew University/Hadassah Medical School Israel
【出 处】
：
BIT Life Sciences 1st Annual World Cancer Congess-2008(2008中
论文部分内容阅读
Cancer results from the interaction of multiple aberrations including activation of dominant oncogenes and upregulation of signal transduetion pathways.An important example of such genes is Vav 1, a cytoplasmic signal transducer protein initially identified as an oncogene.Physiological expression of Vavl is restricted to the hematopoietic system, where its best-known function is as a GDP/GTP nucleotide exchange factor for Rho/RacGTPases, an activity strictly controlled by tyrosine phosphorylation.Vav 1 regulates cytoskeletal rearrangement during activation of hematopoietic cells, as well as activation of JNK, ERK, Ras, NF-kB, and NFAT pathways.It also associates with numerous adapter proteins.Since its discovery, research on Vav1 has cycled between understanding its physiological function in the hematopoiefic system and understanding how it is dysregulated as a truncated oneogene in fibroblasts.
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