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Neurogenic erectile dysfunction (ED) resulting from cavernous nerve injury is a major complication caused by radical prostatectomy (RP).Restoration of erectile function with intracavernous injections of platelet-rich plasma (PRP) or endothelial progenitor cells (EPC) after bilateral cavernous nerve injury in rats are studied in our laboratory.In each study, 24 male Sprague-Dawley rats are randomized into three groups: sham surgery, injured control, and PRP or EPC treatment.Injured-control and PRP or EPC treatment groups are subjected to bilateral CN injury before treatment with vehicle or PRP or EPCs injected into the corpora cavernous, respectively.