As an excellent flexible biomaterial,Bombyx mori silk fibroin materials offer exquisite mechanical,optical,and electrical properties which are advantageous toward the development of next-generation biocompatible electronic devices.In this concern,to re-engineer the hierarchical structure of soft materials and to functionalize the materials are the two common approaches to achieve the functions.This requires the synergy of structures among different levels,which include the re-construction of the hierarchical structure of soft/SF materials at the mesoscale and or Mesoscopic Material Assembly(MMA),which is to add and bind some specific nanomaterials or molecule to the networks so as to acquire some additional functions without jeopardizing the original performance.In this talk,I will cover the principles and strategies of mesoscopic structural re-engineering and functionalization of SF materials based on Intra/inter molecular nucleation.This allows in the design and integration of high-performance bio-integrated devices for future applications in consumer,biomedical diagnosis,and human–machine interfaces.