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<正>目的探讨小管间质纤维化(tubulointerstitial fibrosis,TIF)进程中C型利钠肽(C-type natriureticpeptide,CNP)对基质金属蛋白酶(matrix metalloproteinases,MMPs)及其组织抑制因子(tissueinhibitors of metalloproteinases,TIMPs)的调控效应。方法荧光定量PCR、免疫组化和western blot检测单侧输尿管梗阻(unilateral ureteral obstruction,