Synthesis of Benzimidazole-based Fluconazole Analogues and Relational Antimicrobial Evaluation

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户:forsanwang
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Fluconazole is a well known first-line antifungal drug recommended by World Health Organization and is prevalently used to treat fungal infections by Candida albicans and Cryptococcus neoformans with an exceptional therapeutic record including good activity and favourable pharmacokinetic characteristics.
其他文献
Molecular hybridisation approach is an emerging tool in designing new drug molecules.
The emergence of multiple drug resistant microorganisms has caused major health concern worldwide.
A series of novel quinazolinone benzimidazolyl ethanols with dual-targeting actions were developed and characterized by NMR,IR,MS and HRMS spectra.
Quinolones are one of the most widely prescribed antimicrobial agents as they are generally well tolerated with excellent safety profile,favorable pharmacokinetic characteristics and broad antibacteri
A novel series of quinolone triazoles as antimicrobial agents were designed and synthesized,and their structures were characterized by 1H NMR,13C NMR,IR,MS and HRMS spectra.
:本研究组曾发现2-取代-3,4-二氢-1-异喹啉酮类和3-苄基-4-喹唑啉酮类化合物具有舒张血管的活性[1,2]。本课题合成了30 余种2-苄基-1-异喹啉酮类化合物,采用1H NMR 和HRMS表征目标化合物的结构。
Triazole drugs including Fluconazole,Itraconazole and Voriconazole have been prevalently used in the antiinfective therapy and also exhibit good anti-MRSA potency.
5-Fluorouracil(5-FU)is a well-known antitumour agent widely used for the treatment of solid tumors.However,its clinical use is limited by many disadvantages such as short half-life,low selectivity,and
A series of novel sulfanilamide nitroimidazoles were synthesized via unique C-N cleavage of cyclic sulfanilamides by azole ring.Their structures were characterized by 1H NMR,13C NMR,IR,MS and HRMS spe
A series of Schiff base-appended naphthalimide derivatives were synthesized and characterized by NMR,IR,MS and HRMS spectroscopy.