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糖皮质激素(Glucocorticoid,GC)具备免疫抑制及抗炎效果,被广泛应用于抗移植免疫排斥、自身免疫疾病、感染及肿瘤等治疗。但长期或大剂量使用GC,50%以上的患者会发生骨量流失,是引发继发性骨质疏松症(Osteoporosis,OP)即医源性OP最主要的原因~([1])。中医学认为激素是外源性“纯阳”“邪热”之品~([2]),长期大量作用于人体后导致肾失封藏,肾之阴阳失衡,肾精耗损,肾精亏虚无以充实骨骼,骨失濡养而致OP,属中医“肾虚骨痿”“骨痹”范畴。糖皮质激素性骨质疏
Glucocorticoid (GC) possesses immunosuppressive and anti-inflammatory effects and is widely used in the treatment of immune rejection, autoimmune diseases, infections and tumors. However, the long-term or high-dose use of GC causes bone loss in more than 50% of patients and is the most common cause of osteoporosis (OP), the iatrogenic OP (1). Chinese medicine that hormone is exogenous “pure Yang ” “evil hot ” of the product ~ ([2]), a large number of long-term effect on the body after the loss of renal capsule, kidney yin and yang imbalance, Renal essence deficiency without substantial bone, bone loss Ru Yang and lead to OP, is a Chinese medicine, “Kidney impotence ” “Gubi ” category. Glucocorticoid osteoporosis