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目的:以氟尿嘧啶纳米粒(5-Fu-NP)对聚甲基丙烯酸甲酯(PMMA)人工晶状体进行表面修饰,并测定其体外性质。方法:将壳聚糖、聚丙烯酸与氟尿嘧啶通过滴入分散法制备5-Fu-CS-NP。利用载能离子束技术对PMMA人工晶状体进行5-Fu-NP表面修饰。考察人工晶状体表面纳米粒粒径、含药量以及体外释药特性。结果:表面修饰人工晶状体氟离子束剂量为5×1013～5×1015ions/cm2,表面分布有大小不等的5-Fu-NP球形颗粒,多数小颗粒粒径在100nm以下,少数大颗粒粒径主要集中在100～400nm,含药量为19.55～35.94μg/枚。5-Fu-NP表面修饰人工晶状体能在4d内持续释放药物。结论:5-Fu-NP表面修饰人工晶状体缓释作用较好,有望成为可预防后发性白内障的新型人工晶状体。
Objective: To modify the surface of polymethylmethacrylate (PMMA) intraocular lens with 5-Fu-NP and determine its in vitro properties. Methods: Chitosan, polyacrylic acid and fluorouracil were prepared by instillation dispersion method 5-Fu-CS-NP. 5-Fu-NP surface modification of PMMA intraocular lens was carried out by ion beam implantation. Investigate intraocular lens surface nanoparticle size, drug content and in vitro release characteristics. Results: The dosage of fluoride ion beam of surface-modified intraocular lens was 5 × 1013 ~ 5 × 1015ions / cm2. The size of 5-Fu-NP spherical particles was distributed on the surface. Most of the small particles were below 100 nm in size. Mainly concentrated in the 100 ~ 400nm, with a dose of 19.55 ~ 35.94μg / piece. 5-Fu-NP surface-modified intraocular lens in 4d sustained release of drugs. CONCLUSION: The 5-Fu-NP surface-modified intraocular lens (IOL) has good sustained-release properties and is expected to become a new type of intraocular lens for the prevention of idiopathic cataract.