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5. Rare variant association analysis via likelihood-based statistical inference

Rare variant association analysis via likelihood-based statistical inference

来源 :泛华统计学会(icsa)2015年学术会议 | 被引量 : 0次 | 上传用户：zlq5626

【摘 要】

：

　　Background: With the advance of next generation sequencing technologies,identifying rare variants associated with phenotypes of interest has become feasible

【作 者】

：

Yang Zhao 

【机 构】

：

NanjingMedicalUniversity,Nanjing,China

【出 处】

：

泛华统计学会(icsa)2015年学术会议

【发表日期】

：

2015年7期

【关键词】

：

Rare variants Likelihood ratio test (LRT) Restricted likelihood ratio test (ReLR 

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论文部分内容阅读

　　Background: With the advance of next generation sequencing technologies,identifying rare variants associated with phenotypes of interest has become feasible.However,rare variant association analysis is rather challenging due to the low minor allele frequency and traditional methods for common variants are underpowered.

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