A Modular Vaccine Development Platform Based on Sortase-Mediated Site-Specific Tagging of Antigens o

来源 :第十一届全国病毒学学术研讨会暨第六届武汉现代病毒学国际研讨会 | 被引量 : 0次 | 上传用户:udbjqr
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Virus-like particles (VLPs) can be used as powerful nanoscale weapons to fight against virus infection.In addition to direct use as vaccines,VLPs have been extensively exploited as platforms on which to display foreign antigens for prophylactic vaccination and immunotherapeutic treatment.
其他文献
目的:探索应用长爪沙鼠(Meiiones Unguiculataus Milme-Edwauds)构建HEV动物模型的可行性。方法:本实验从猪粪便稀释悬液中提取HEV RNA并鉴定,经腹腔和口服接种HEV于长爪沙鼠,并每周采集血液、相关器官(心、肝、脾、肺、肾、肠系膜淋巴结、脾脏)及粪便。用RT-N-PCR和免疫组化等检测方法分析各个样品。
Objectives:Human metapneumovirus (HMPV) is a worldwide distributed pathogen of the respiratory tract.The objectives of this study were to identify HMPV A and B genotypes among the influenza-like illne
会议
The newly discovered zoonotic disease,severe fever with thrombocytopenia syndrome (SFTS) caused by a novel phlebovirus SFTS bunyavirus (SFTSV),was identified since 2009 in multiple provinces in China.
会议
蝙蝠冠状病毒(BatCoVs)-HKU4和-HKU5与MERS-CoV具有密切的系统发生关系.BatCoVs-HKU4和BatCoVs-HKU5的S蛋白与MERS-CoV的S蛋白的高同源性促使我们探索BatCoVs-HKU4与BatCoVs-HKU5是否也可以与MERS-CoV的受体hCD26结合进而介导病毒入侵.
会议
Currently,the HIV pandemic remains a major global health challenge.In order to effectively control and cure HIV-1 infection,it is necessary to perform greater studies on host-HIV interactions and deve
会议
The 5cap structures of eukaryotic mRNAs are important for RNA stability and protein translation.Many viruses that replicate in the cytoplasm of eukaryotes have evolved 2-O-methyltransferases (2-O-MTas
会议
马传染性贫血病毒(EIAV)弱毒疫苗是通过经典弱毒疫苗致弱方式研制成功的首例慢病毒弱毒疫苗。为深入研究EIAV弱毒疫苗致弱机制,从基因水平确定影响病毒毒力和免疫原性的因素,本研究对EIAV疫苗株和亲本强毒株以及疫苗致弱过程中第3个中间代次(32代、62代和92代)病毒株的前病毒基因组进行测序分析。
登革热是一种由登革病毒感染引起,经蚊虫传播的传染性疾病.近年来,登革热疫情在热带和亚热带地区重复爆发并逐年加重.全球每年被感染的人数预计已达到3.9亿,其中约9600万感染者发展为症状性疾病,包括登革热、登革出血热、以及登革休克综合征.
会议
A pseudorabies virus(PRV)variant with enhanced pathogenicity has emerged in many vaccinated swine herds in China since 2011.rPRVTJ-delgE/gI,a previously described gE/gI-deleted PRV based on the PRV va
Classical swine fever(CSF)is an economically important infectious disease of pigs caused by classical swine fever virus(CSFV).Pseudorabies(PR),which is caused by pseudorabies virus(PRV),is another imp