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Purpose Our earlier studies revealed that gain of chromosome 5p was often seen in Esophageal squamous cell carcinoma.The gene of SKP2,located on chromosome 5p13,plays a critical role in cell cycle progression through its control of several cell cycle regulator proteins.The present study aimed to evaluate the amplification and expression status of SKP2 gene and its function in Esophageal squamous cell carcinoma (ESCC).