ROS inhibitors improve reduction of Na+/H+ exchanger (NHE) activity by intermittent hypoxia in neona

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户:qq104397622
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Aim: To investigate whether ROS inhibitors could improve the effect of intermittent hypoxia (IH) for 1-4 d on ability to recover from acidosis in cardiomyocyte.Methods: Neonatal cardiomyocytes were treated with IH (alternating 5% O2 30 min,20% O2 30 min) for 1, 2, 3, and 4 d.Cells were acid loaded with NH4Cl, and rates of pHi recoveryand acidification were measured by BCECF-AM loading.
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