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Objective: We evaluated autoimmunity as a potential cause of Menieres disease, and tried to find biomarkers for the diagnosis of the disease.Methodology: We investigated the protein composition of human inner ear fluid using liquid column mass spectrometry,the autoimmune reaction between circulating autoantibodies in patient serum and multiple antigens using the Protoarray(①)system, the immune reaction between patient serum and mouse inner ear tissues using western blot analysis, and the association between the occurrence of the immune reaction and clinical features of the patients.