组蛋白赖氨酸特异性去甲基化酶1(LSD1)是2004 年由哈佛大学Shi Yang 教授首次发现并在Cell 杂志报道的第一个组蛋白赖氨酸特异性的去甲基化酶,其后的系列研究发现LSD1 动态调节组蛋白的甲基化状态并调控基因的转录,激活和转录后修饰,在表观遗传学方面起重要作用。
Preliminary biological data on 7-anilino-6-azaindoles(8–11)suggested that hydrophobic substituents at C-7 contribute to the enhancement of antiproliferative activity.
The nuclear estrogen-related receptor ?(ERR?)plays a central role in the regulation of expression of the genes involved in mitochondrial biogenesis and oxidative metabolism.Small molecular ERR? agonis
2013 年6 月17 日,相关的国际组织宣布第41 届世界超级计算机(HPC)500 强排名,我国广州超算中心的天河-2 以峰值计算速度达到每秒5.49 亿亿次夺冠.一般认为:HPC 可以加快生物医药创新.我们的实验表明,采用分子动力学为基础的虚拟筛选(MDVS),HPC 可以显著加快生物医药创新.本文报告在天河-2 先导系统上进行的有关药物设计技术的最新进展,和将高效能计算落实到高效能药物发现
Protein-protein interactions(PPI)play a vital role in various biological processes.Small-molecule compounds targeting protein-protein interactions can be developed into drug candidates or used as chem
Human neutrophil elastase(HNE)has been identified as a potential therapeutic target for the discovery of anti-inflammatory drugs for decades.However,the HNE-targeting drug discovery has achieved littl