【摘 要】
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Objective: To assess the efficacy and safety of DENG Tie-tao Nuanxin Capsule(邓铁涛暖心胶囊,DTTNXC) for patients with heart failure (HF).Methods:a systematic literature search was performed in 6 databases: P
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Objective: To assess the efficacy and safety of DENG Tie-tao Nuanxin Capsule(邓铁涛暖心胶囊,DTTNXC) for patients with heart failure (HF).Methods:a systematic literature search was performed in 6 databases: Pub Med,(Excerpt Medica Database),Chinese National Knowledge Infrastructure (CNKI),Wanfang Data Information Site,Chinese BioMedical Database (CBM),VIP Chinese Science and Technique Journals Database from the date of its inception up to November 2016.Review Manager 5.2 software was used for assessment of risk of bias,data synthesis and subgroup analysis.Results: Twelve trials involving 968 participants were eligible.Compared with Western medicine (WM) alone,DTTNXC plus WM showed statistical significance in total effective rate (Risk ratio 1.17,95%CI 1.10 to 1.24).According to subgroup analysis,the 6-months group and the 12-months group have better effect than the 3-months group.As for six-minute walking distance,DTTNXC plus WM compared with WM has significantly increased walking distance (Weighted mean difference 32.67,95%CI 16.83 to 48.50).DTTNXC plus WMhas significantly decreased in mortality (RR 0.30,95%CI 0.16 to 0.57) and re-admission rate (RR 0.45,95%CI 0.33 to 0.61) compared with WM.DTTNXC plus WM was beneficial for B-type natriuretic peptide (-240.47,95%CI-332.45 to-148.49).Conclusions: Despite of the apparently positive findings,we cannot draw a sound conclusion that DTTNXC has positive effect in patients with heart failure,because of the insufficient evidence.
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