继发性甲状旁腺功能亢进症(Secondary hyperparathyroidism,SHPT)是由于钙磷代谢异常、维生素D缺乏或肾功能损害,引起甲状旁腺增生,血甲状旁腺激素(Parathyroid hormone,PTH)升高,进而加重骨骼损害的疾病.SHPT是衰老人群及慢性肾病(Chronic kidney disease,CKD)患者常见的并发症之一.CKD患者常常在早期即出现SHPT,且病
Background Hypertriglyceridemia (HTG) is the most common feature of dyslipidemia in the states of insulin resistance and type 2 diabetes mellitus (T2DM).And we have found the genetic variants contribu
AIM To investigate antiapoptotic effect and mechanism of human tissue inhibitor of metalloproteinases-1 on diabetic wound healing.METHODS 40 male SD rats were induced diabetes by intra-abdomen injecti
Objective Obesity is considered as low-grade chronic disease associated with increased production of adipokines,pro-inflammatory cytokines,leptin ect.Studies have shown that there are increased white
Background and objective Insulin resistance (IR) is closely correlated with cardiovascular diseases (CVDS).Retinol-binding protein 4 (RBP4) is a novel adipokine that may be a predictor of cardiovascul
Objective Lipoprotein(a) [Lp(a)],a low density lipoprotein-like particle,has been proposed as a causal genetic risk factor for cardiovascular disease (CVD) among general populations.Since diabetes pre
Background Metabolic syndrome (MS) is becoming more and more comment.Obesity,recognized as the central part of MS,has been defined mainly according to waist circumference (WC) and body mass index(BMI)
Backgrounds and Objectives Plasma proinsulin/insulin ratio which reflects b-cell dysfunction is elevated in patients with type 2 diabetes.Clinical studies have demonstrated that glucagon like peptide-
Background The developmental origins of health and disease (DOHaD) hypothesis proposes that nutritional disturbances during critical periods of early life development can significantly impact the pred
目的 探讨血清甘油三酯(TG)水平对初诊妊娠期糖尿病(GDM)患者的胰岛β细胞功能及胰岛素抵抗的影响.方法 纳入2012年1月至2014年4月人住于上海交通大学附属第一人民医院产科病房,孕24-30周的439例初诊GDM患者.收集其一般资料、血脂,行75g口服葡萄糖耐量试验和胰岛素释放试验,计算稳态模型评估b细胞功能指数(HOMA-β)、稳态模型评估胰岛素抵抗指数(HOMA-IR)和定量胰岛素敏感