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The genus Illigera belong to the family of Hemandiaceae and consists of about 30 species mainly distributed in the tropical regions of Africa and Asia.1 llligera cordata has been used for the treatment of rheumatic arthralgia,fracture,and traumatic injuries in traditional Chinese medicine,especially in Yi tribal folk medicine.1 However,the chemical constituents of I.cordata have not been reported yet.Phytochemical investigation on the chemical constituents from the extract of the aerial parts of I.cordata led to the isolation of six rare monoterpenoid derivatives,cordanoids A-F (1-6),biosynthesized via a plausible cyclization between the ortho-quinone methide and exocyclic enone.2 The structures were elucidated by extensive NMR experiments,high-resolution electron ionization mass spectrum,chiroptical properties,and crystal X-ray diffraction analysis.Moreover,studies on the anti-inflammatory bioactivity to inhibit NO production of LPS-stimulated RAW264.7 macrophages of all isolates are in progress.