【摘 要】
：
We investigate the cytoprotective effects and molecular mechanism of genistein in oxidative stress-induced injury using an endothelial cell line (EA.hy926).
【机 构】
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Research Center for Nutrition and Food Safety,Institute of Military Preventive Medicine,Third Milita
【出 处】
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2012第二届中韩植物化学物国际学术研讨会
论文部分内容阅读
We investigate the cytoprotective effects and molecular mechanism of genistein in oxidative stress-induced injury using an endothelial cell line (EA.hy926).An oxidative stress model was established by incubating endothelial cells with H2O2.According to our results,genistein pretreatment protected endothelial cells against H2O2-induced decreases in cell viability and increases in apoptosis.Genistein also prevented the inhibition of Bcl-2 and activation of caspase-3 induced by H2O2.Genistein increased superoxide dismutase (SOD),catalase (CAT) and glutathione (GSH) levels and attenuated the decrease of these antioxidants during oxidative stress.We also found that genistein induced the promoter activity of both nuclear factor-erythroid 2-related factor 2 (Nrf2)and peroxisome proliferators-activated receptor-gamma (PPARγ).Additionally,genistein induced the nuclear translocation of Nrf2 and PPARy.
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