【摘 要】
:
OBJECTIVE: To examine the possible association between the G-395A polymorphism in the promoter region of the KLOTHO gene and cognitive impairment among Chinese nonagenarians and centenarians.METHODS:
【机 构】
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The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University
【出 处】
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2015中国老年医学和老年健康产业大会
论文部分内容阅读
OBJECTIVE: To examine the possible association between the G-395A polymorphism in the promoter region of the KLOTHO gene and cognitive impairment among Chinese nonagenarians and centenarians.METHODS: Data were from the Project of Longevity and Aging in Dujiangyan (PLAD) study.The genotyping of G-395A (rs1207568) in the promoter region of the KLOTHO gene was performed using the TaqMan allelic discrimination assay.Cognitive function was assessed with the Mini-Mental Status Examination (MMSE).Age, gender, educational level, cigarette smoking, alcohol drinking, hypertension, diabetes and other potential confounders were also evaluated.
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