A serum metabolomic investigation of cholestasis on an experimental model of bile duct ligation in r

来源 :中华医学会第22次全国麻醉学术年会 | 被引量 : 0次 | 上传用户：tina_lh

【摘要】

：

【作者】

：

Long Y DongX Chen JY Wang L Huang JQ Sun YM Yu WF

【机构】

：

Department of Anaesthesiology, Eastern Hepatobiliary Surgical Hospital, Second Military Medical Univ

【出处】

：

中华医学会第22次全国麻醉学术年会

【发表日期】

：

2014年11期

【关键词】

：

metabolomics cholestasis bile duct ligation serum liquid chromatography-mass spe

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

Metabolomics follows the changes in concentrations of endogenous metabolites,which may reflect various disease states as well as systemic responses to environmental, therapeutic, or genetic interventions.1ln this study, we applied metabolomic approaches to monitor dynamic changes in plasma metabolites, and compared these metabolite profiles in bile duct ligation rats (an animal model of cholestasis) with those in the parent strain of Sprague-Dawley (SD) rats in order to characterize cholestasis pathophysiologically.

其他文献

皮层下机制在睡眠和麻醉诱导中的作用

背景最近的研究表明丙泊酚和右美托嘧啶等全身麻醉药和镇静药作用于各自特异性分子靶点,但他们在神经网络层面是否也具有特异性作用却不得而知.有证据表明,脑皮质在麻醉或睡眠时可引起"top-down"抑制,但也有一些研究显示这些药物是通过皮层下机制发挥镇静作用,并且很可能与自然睡眠的神经网络路径一致.目的本研究旨在揭示睡眠与麻醉机制在神经网络层面的相似性,并证实在意识消失过程中,脑内不同核团的变化差异

会议

Electro-acupuncture reduces myocardial ischemia-reperfusion injury by down-regulating Egr-1 expressi

Early growth response (Egr)-1 is an upstream master switch in controlling inflammatory responses following myocardial ischemia-reperfusion (I/R).1 Activation of extracellular signal-regulated protein

会议

ElectroacupunctureEgr-1ERK1/2myocardial I/R

高压氧预处理脑保护效应血清生物标志物的筛选

目的由于手术病人自身心脑血管疾病、外科操作和麻醉等原因,围术期脑缺血损伤并不少见且后果极其严重.我们前期研究发现高压氧等非缺血预处理措施可诱导显著的脑保护效应.然而,在我们的大样本研究中发现一个重要问题,预处理措施并不能使所有动物或患者从中受益.为什么相同的预处理措施会产生不同的效应?由于动物/患者间显著的个体差异,每一接受预处理的个体需要接受不同程度的处理才能激活其内源性保护机制,诱导缺血耐受

会议

The effects of hydrogen gas inhalation on cerebral oxidative stress and inflammation after intestina

Intestinal ischemia/reperfusion (Ⅱ/R) is associated with high morbidity and mortality, and recent increasing data have shown that hydrogen gas (H2) can neutralize free radicals and reduce oxidative st

会议

Hydrogenintestinal reperfusion injuryMicrogliaOxidative stressInflammation

特异性控制神经元活性法研究睡眠和全麻药机制新进展

麻醉和睡眠本质上不同,但在某些环节可能有相似之处.研究显示:脑内存在睡眠和觉醒两大调节系统,分别由众多的神经核团和递质(调质)组成,受内源性睡眠调节物质和生物节律的调控.觉醒系统包括:脑干网状结构、臂旁核谷氨酸能神经元、蓝斑核去甲肾上腺素能神经元、中缝背核5-羟色胺能神经元、中脑多巴胺能神经元、外背侧被盖核/脚桥被盖核/脑桥-中脑/基底前脑乙酰胆碱能神经元、下丘脑后部结节乳头核(tuberomam

会议

Electroacupuncture attenuates cerebral ischemic injury through adiponectin receptor 1 mediated signa

Both type 1 and type 2 diabetes mellitus substantially increase the risk for cerebral ischemic reperfusion injury.In addition, cerebral ischemic reperfusion injury is one major cause of morbidity and

会议

Diabetes MellitusCerebral Ischemia Reperfusion InjuryElectroacupunctureOxidat

Screening and bioinformatics analysis of the specific microRNAs involved in the protective effects o

Ischemic preconditioning (IPC)-mediated cardioprotection has been reported impaired in some pathological conditions 1.Previous studies from our laboratory showed that the cardioprotection of IPC was s

会议

heart failurecardiomyocytesmorphine preconditioningmicroRNA microarraybioinf

HSPA12B protects endothelial cells against endotoxin challenge by inhibiting p38 MAPK phosphorylatio

Endothelial barrier dysfunction is the hallmark of acute lung injury or acute respiratory distress syndrome, involving complicated inflammatory activation and cellular changes, which is far away from

会议

HSPA12Bendothelial cellsendotoxinp38 mitogen-activated protein kinaseacute r

Neuroprotective Gases-Fantasy or Reality for Clinical Use?

Injury to the central nervous system has baffled the human being for ages.Until now, no medical measurements have been proved clinically to reduce CNS injury effectively except for tPA against ischemi

会议

Association of glycemic variability and acute kidney injury in cardiac surgery patients

Previous clinical studies have well demonstrated a strong relationship between sustained chronic hyperglycemia (measured by HbA1c) and diabetic complications.Now, a growing body of evidence shows that

会议

glycemic oscillationacute kidney injurycardiac surgery

A serum metabolomic investigation of cholestasis on an experimental model of bile duct ligation in r

与本文相关的学术论文