Aim: Tolerogenic dendritic cells (DCs) are well-known to show an immunosuppressive function.In this study, we determine the therapeutic effects and potential mechanisms of transferred bone marrow (BM) CDllb+ F4/80+ DCs on collagen-induced arthritis (CIA) in the model mice.Methods: Murine BM CD11b+ F4/80+ DCs were generated under the stimulation of GM-CSF and IL-4 and then transferred to CIA mice by three intravenous injections.The joint and spleen histopathology was evaluated thereafter.The effects of transferred DCs on T lymphocytes were analyzed by determining proliferation capacity,numbers/percentages of Treg and Thl7 subsets, cytokine production, and expressions of Foxp3, Helios and RORγt.