Purpose: The object of this study was to investigate prognostic values of intratumoral p21-activated kinase 6 (Pak6) expression in patients with clear-cell renal cell carcinoma (ccRCC).Methods: The immunohistochemistry in tissue microarray was used to evaluate the expressionof Pak6 in 104 patients had undergone nephrectomy at Zhongshan Hospital of FudanUniversity.Prognostic value and clinical outcomes were evaluated.