【摘 要】
：
G-quadruplexes represent a family of nucleic acid secondary structures which can be formed by certain guanine-rich sequences in the presence of monovalent cations and are stabilized by G-quartets.[1]O
【机 构】
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CNRS Institut Curie France
【出 处】
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中国上海第七届国际新药发明科技年会
论文部分内容阅读
G-quadruplexes represent a family of nucleic acid secondary structures which can be formed by certain guanine-rich sequences in the presence of monovalent cations and are stabilized by G-quartets.[1]Over the past ten years,the occurrence of quadruplex structure in DNA and RNA has attracted considerable research effort.A wealth of knowledge has accumulated concerning G-quadruplex motifs and their potential role in various DNA-and RNA-related processes such as recombination,telomere maintenance,transcription,and more recently splicing.[2] These structures can be considered as particular receptors for small molecules,their recognition allowing in turn targeting of a given G-rich sequence.In particular,stabilizing formation of G-quadruplex at telomeric DNA using synthetic compounds is currently investigated as a novel approach to induce apoptosis in cancer cells.Our research has led to the emergence of several chemical series of high affinity and selectivity for the telomeric G-quadruplex DNA [3].These will be presented and the biological effect of the new drugs will be discussed.
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