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The one reason of production of aneuploid and abnormal development in embryo is missegregation of Chromosome in oocyte.CDC20 (cell division cycle 20 homolog, CDC20) bears a fairly strict relationship to cell cycle and is the activating factor of anaphase-promoting complex/cyclosome(APC/C) as well as the target of spindle assembly checkpoint (SAC).CDC20 is targeted for destruction by early APC/C activity and needs to be resynthesized during metaphase I to enable anaphase onset.APC/C can be activated by CDC20 and the activity of APC/CCDC20 can lead to degradation of securin, separase is activated after the degradation of securin.Finally, Chromosome segregation is driven by the activity of separase.