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Aim: To observe the effects of total saponins of Chaenomeles speciosa (TSCS) on synovial pathology,synovial mast cell degranulation and tryptase expression and to investigate the relationship between the functions of mast cells and effects of TSCS on adjuvant arthritis (AA) in rats.Methods: Male Wistar rats were randomly divided into normal control group,model group and TSCS group (200 mg/kg),n=15 in each group.