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In Macau,Epilepsy is quite common in patients with brain tumours ( 12.6％ ),which can substantially affect daily life,even if the tumour is under control.Several factors affect the mechanism of seizures in brain tumours,including tumour type,tumour location,and peritumoral and genetic changes.Prophylactic use of antiepileptic drugs is recommended in some types of brain tumours,and potential interactions between antiepileptic and chemotherapeutic agents persuades against the use of enzyme-inducing antiepileptic drugs.Multidrug-resistance proteins prevent the access of antiepileptic drugs into brain parenchyma,which partly explains why seizures are frequently refractory to treatment.Surgical resection of brain tumour and the epileptogenic area may render patients seizure-free.Removal of the tumor alone may also be associated with an excellent survival rate and surgical outcome.Conventional neurosurgical procedures are restricted in patients with tumors that are deepseated lesions or involve functional cerebral cortex.Computer-assisted stereotactic surgical procedures have been developed for biopsy and resection of intra-axial brain-mass lesions.Stereotactic tumor resection may allow pathological determination of intracranial lesions and produce a worthwhile reduction in seizure activity in some patients with intractable partial epilepsy.