【摘 要】
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Mesenchymal stem cells (MSCs) are the adult progenitor cells for the mesodermal lineages of adipocytes, osteoblasts, chondrocytes, and fibroblasts.Recent re
【出 处】
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第11届海峡两岸细胞生物学学术研讨会
论文部分内容阅读
Mesenchymal stem cells (MSCs) are the adult progenitor cells for the mesodermal lineages of adipocytes, osteoblasts, chondrocytes, and fibroblasts.Recent reports show that these stem cells possess strong immunomodulatory properties-including expansion of immunomodulatory leukocytes such as regulatory T lymphocytes and tolerogenic dendritic cells-that are clinically relevant.Interestingly,mechanistic studies have revealed that many similarities exist between MSC immunomodulation and cancer immune evasion.Our lab has a long-standing interest in delineating mechanisms of action for these properties.We demonstrated that human MSC-secreted hepatocyte growth factor (HGF) can expand CD14-CD11b+CD33+ myeloid-derived suppressor cells (MDSCs) as well as rapidly convert CD14+ monocytes into an immunomodulatory, interleukin (IL)-10-secreting phenotype.Most recently, we have found that MSCs can suppress IL-17-expressing CD4 cells (Th17) responses through a secreted factor and STAT3 to modulate surface expression of Programmed Death-Ligand 1 (PD-L1) , a potent ligand of the immune checkpoint Programmed Death-1 (PD-1).Our data suggest that mechanistic understanding of human MSC immunomodulation may yield targets for therapeutic application in both immune-mediated diseases as well as cancer.
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