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Background: Abnormalities of brain energy metabolism are involved in Alzheimers disease (AD).Sirtuin 1 (SIRT1) is a class Ⅲ histone deacetylase and activates peroxisome proliferator-activated receptor-γ, co-activator-1α (PGC-lα), which enhances mitochondrial biogenesis and energy homeostasis.Electroacupuncture (EA) has been reported to improve brain energy metabolism in AD.However, the effect of EA on SIRT1 and PGC-1α in AD remains unclear.Material/Methods: ATP levels were measured using assay kits in the hippocampus and frontal cortex of senescence-accelerated mouse prone 8 (SAMP8) mice.Western blotting analysis and quantitative real-time RT-PCR were performed to measure the expression of SIRT1 and PGC-1α in the hippocampus of SAMP8 mice.PGC-1α acetylation was analyzed using immunoprecipitation.Results: Compared with senescence-accelerated resistant mice 1 (SAMR1) mice, SAMP8 mice had a decline in ATP levels and the expression of SIRT1 and PGC-1α.EA treatment improved ATP levels, upregulated the expression of SIRT1 and PGC-1α, and decreased PGC-1 α acetylation.Conclusions: These data suggest that EA improved brain energy metabolism, potentially associated with the upregulation of SIRT1-dependent PGC-1 α expression.