To better understand the molecular basis of hsa-miR-1908 in obesity, we examined human multipotent adipose-derived stem (hMADS) cells genes differentially expressed in hsa-miR-1908 over-expressed hMADS cells and hMADS cells as control using cDNA microarrays.We constructed the lentiviral vector containing miR-1908 with high overexpression in infected hMADS cells.cDNA microarrays containing 34127 genes were used to investigate gene expression of hMADS cells.The analysis of gene expression profiles indicated that 69 genes were upregulated and 54 genes were down-regulated in hsa-miR-1908 over-expressed hMADS cells.This study provides a new view on the study of hsa-miR-1908 unraveling some of the molecular events taking place in hMADS cell and will add candidate genes for future investigation.