SET Up-regulated Key Steroidogenic Enzymes and Androgen Production in PCOS

来源 :中华医学会第七次全国生殖医学学术会议 | 被引量 : 0次 | 上传用户:coolsun070279
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Objective In previous study by microarray, we found that the e.xpression of SET gene was up-regulated in polycystic ovary syndrome (PCOS) ovaries.Some evidence suggested that SET gene was essential for regulating both the promoter activity of CYP17 and the biological activity of P450c17.Therefore, SET gene may be an attractive candidate regulator involved in the hyperandrogenism of PCOS.
其他文献
Objective To determine the impact of gonadotropins, either single or in combination in a dose-response manner on the rates of oocytes maturation, fertilization and early embryo development in vitro.De
会议
Problem Although previous studies indicated a possible negative impact of antinuclear antibodies(ANA) on the outcome of IVF-ET , the limited available information does not lead to a definite conclusio
会议
目的 探讨无精子患者血清抑制素B与睾丸抽吸(TESE)成功率的关系.方法 血清抑制素B采用双抗夹心酶联免疫吸附技术,血清FSH采用化学发光法检测.结果 回顾性分析了91例无精子症患者的FSH及血清抑制素B水平,其中42例非梗阻性无精子症患者血清抑制素B水平(53.18 ±27.26)明显低于45例正常对照组(129.58±56.6),差异有显著性(P<0.05),血清FSH水平(19.18±13.
会议
Thyroid disease is one of the most common endocrine disorders for women of reproductive age.Although it is well accepted that infertile women with overt hypothyroidism should be treated with an adequa
会议
目的 探讨不同绒毛膜促性腺激素(HCG)剂量对体外受精-胚胎移植结局的影响.方法 回顾性分析2011年3月~2012年12月在我中心进行体外受精-胚胎移植(IVF-ET)的患者,共397周期,选择获卵数≥20的69个周期,均采用促性腺激素释放激素激动剂(GnRHa)长方案降调节,依据HCG用量分为A、B两组,A组25例,HCG用量4000-6000IU,B组44例,HCG用量10000IU.比较两
会议
目的 比较促性腺激素释放激素激动剂长效长方案和短效长方案对体外受精-胚胎移植结局的影响.方法 回顾性分析2011年1月至2012年5月在我院行IVF或ICSI的周期资料,入组标准:1.患者在以上时间段内在我院生殖中心进行IVF/ICSI共两个周期;2.均采用黄体期长方案降调节,其中一次为长效长方案(GnRH-a 0.8或1.0mg皮下注射一次),另一次为短效长方案(GnRH-a 0.05或0.1m
会议
胚胎成功植入受到宫腔病理学因素、子宫内膜厚度、凝血倾向和免疫等多种临床因素的影响,其中任何一个因素有缺陷均有可能导致胚胎植入失败.胚胎反复植入失败(repeatedimplantation failure,RIF)不仅对患者的身心造成了巨大打击而且加重了患者的经济负担,已成为辅助生殖技术中的一大困境.因此,我们必须积极探寻RIF的原因及应对策略,以改善IVF-ET的结局.
会议
Backgroud Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders occurring to women.However, the relationship between hyperandrogensim and the clinical signs of androgen excess
会议
Recently, several studies focused on the safety of fetus or offspring derived from assisted reproductive technology (ART) which might be suspected to result in more maternal and infant complications t
会议
Objective Activin A was one of the altered expression cytokine, which up-regulated in the women with endometriosis.Investigation of Activin A in human endometrial stromal cells (ESCs) will explain the
会议