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The fibroblast growth factors (FGFs) are important for embryo development, wound healing,hematopoiesis, and angiogenesis.FGF-1, a member of FGF family, is involved in both receptor-dependent pathways and an intracrine pathway.Studies have recently shown that FGF-1 is overexpressed in the early stages of several kinds of cancer.Thus, FGF-1 is a candidate for cancer immunotargeting.To study the potential use of therapeutic antibodies against FGF-1, a monoclonal hybridoma 1C9 secreting monoclonal antibody specific for FGF-1 was developed.