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Objectives Pyridoxamine,a potent advanced glycation end products(AGEs)inhibitor,has been regarded as a prospective pharmacological agent in attenuating hypertensive renal injury.The aim of this study was to explore the effect of pyridoxamine on Angiotensin Ⅱ(Ang Ⅱ)-induced proliferation of human proximal tubular epithelial cells(HK-2)by comparison with telmisartan.