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  5. Polyethylenimines modified by amino acids with different charge states and hydrophilic/hydrophobic p

Polyethylenimines modified by amino acids with different charge states and hydrophilic/hydrophobic p

来源 :The Third Symposium on Innovative Polymers for Controlled De | 被引量 : 0次 | 上传用户：ytx45
【摘 要】
：
Gene therapy appears to be a promising method in cancer therapy.Gene carrier is an essential factor for a successful gene therapy [1].The potential of 25 kDa polyethylenimine (PEI25k) in gene therapy
【作 者】
：
Ying Zhang Huayu Tian Xiuwen Guan Huapan Fang Nan Yan Xuesi Chen 
【机 构】
：
Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of S
【出 处】
：
The Third Symposium on Innovative Polymers for Controlled De
【发表日期】
：
2014年6期
【关键词】
：
amino acid gene delivery gene transfection PEI25k 
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　　Gene therapy appears to be a promising method in cancer therapy.Gene carrier is an essential factor for a successful gene therapy [1].The potential of 25 kDa polyethylenimine (PEI25k) in gene therapy is limited by its low efficiency and high cytotoxicity.Because amino acids show excellent properties in gene expression regulation [2],we investigated the effects of conjugating PEIs with different kinds of amino acid monomers on the transfection efficiency of PEIs in vitro.
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