斑马鱼gtsf1基因的表达及功能初步分析

来源 :第三届全国斑马鱼研究大会 | 被引量 : 0次 | 上传用户：GOUGOU2929

【摘要】

：

　　Gametocyte-specific factor 1(gtsf1)是一个进化上高度保守与生殖系统发育相关的基因.Gtsf1 在小鼠胚胎雌雄性腺的生殖细胞中高表达.在出生后小鼠的卵母细胞成熟过程中

【作者】

：

周安莉胡雨姚纪花

【机构】

：

复旦大学生命科学学院遗传工程国家重点实验室,上海200433

【出处】

：

第三届全国斑马鱼研究大会

【发表日期】

：

2013年10期

【关键词】

：

斑马鱼 gtsf1 胚胎发育性腺功能分析

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　　Gametocyte-specific factor 1(gtsf1)是一个进化上高度保守与生殖系统发育相关的基因.Gtsf1 在小鼠胚胎雌雄性腺的生殖细胞中高表达.在出生后小鼠的卵母细胞成熟过程中都有表达，且局限在细胞质中.雄性仅在出生后的早期小鼠精巢的精原细胞前体中表达.Gtsf1 敲除的小鼠雌性可育，而雄性个体则出现生殖细胞大量凋亡致不育.果蝇中该基因的突变引发转座子的去抑制及卵巢的滤泡层缺失，雌性不育.Gtsf1 缺失对雌体小鼠和果蝇育性造成的不同影响引起了我们的关注.我们拟以斑马鱼作模式生物，探讨gtsf1 基因在胚胎尤其是性腺发育中的功能及可能的机制，为深入了解动物生殖细胞的发生和分化提供重要的资料.

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斑马鱼gtsf1基因的表达及功能初步分析

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