Among the 1356 API (Active Pharmaceutical Ingredient) approved by FDA up to the end of 2006, 51.4% are in salt forms, with 38.6% formed from basic molecules and 12.8% formed from acidic molecules.Its very important that pharmaceutical counterions and residual salts were determinate.Dionex Acclaim trinity Plhas chromatographic properties of reversed-phase/ cation-exchange/ anion-exchange trimodal stationary phases.The stationary phase was based on high-purity porous spherical silica particles coated with ion-exchange beads.Its possible that we can use Dionex Acclaim trinity P1 to separate cations and anions simultaneouly.