• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. Association between insulin receptor substrate-1 genotypes and clopidogrel resistance in patients wi

Association between insulin receptor substrate-1 genotypes and clopidogrel resistance in patients wi

来源 :第十二届中国介入心脏病学大会(CIT2014) | 被引量 : 0次 | 上传用户：xdlclub
【摘 要】
：
Background To investigate the possible association between insulin receptor substrate-1 (IRS-1) genotypes and clopidogrel resistance (CR) in Chinese patients with type 2 diabetes mellitus and coronary
【作 者】
：
Zhang Dingyu Zhang Xiaolin Liu Dan Han Yaling 
【机 构】
：
Department of Cardiology,Institute of Cardiovascular Research of People's Liberation Army,Shenyang
【出 处】
：
第十二届中国介入心脏病学大会(CIT2014)
【发表日期】
：
2014年3期
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Background To investigate the possible association between insulin receptor substrate-1 (IRS-1) genotypes and clopidogrel resistance (CR) in Chinese patients with type 2 diabetes mellitus and coronary artery disease.Methods A total of 690 hospitalized patients with type 2 diabetes rnellitus and coronary artery disease in General Hospital of Shenyang command between April 2011 and April 2013 were enrolled.The residual platelet aggregation rate (RPA) induced by 20 μmol/L of adenosine diphosphate (ADP) was detected by optical nephelometry.Clopidogrel resistance was defined by RPA ≥70％.All the participants were divided into CR group and NCR group by RPA.The association between IRS-1 genetic variant and platelet function was assessed in patients with type 2 diabetes mellitus and coronary artery disease.
其他文献
The involvement of phosphatase and tensin homolog deleted on chromosome ten in the regulation of apo
Background Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a protein that accelerates apoptosis in different types of cells in response to various stimuli and is down-regulated in m
会议
ANGPTL4 enhances microvascular integrity by preventing human cardiac microvascular endothelial cells
Background Ischemia disrupts microvascular barrier function in ischemic region of myocardium.This causes microvascular leak,edema and leucocytes diapedesis,resulting in uncontroled inflammation and is
会议
Regulation of AT1-Calcineurin-NFAT pathway on stretch-induced remodeling of Ito in cultured atrial n
Background The ion channel remolding of atrial myocytes induced by increased atrial load and mechanical force stretch plays an important role on the generating,development,and sustention of atrial fib
会议
Blocking the mitochondrial permeability transition pore with cyclosporine-a can restore cardioprotec
Background Ischemic postconditioning (IPO) reduces lethal reperfusion injury under normal conditions,but its effectiveness is blocked by hypercholesterolemia (HC).This study aims to determine whether
会议
Effect and possible mechanism of PDGFs/PDGFRs signaling pathway on myocardial fibrosis in DOCA/salt
Background To investigate the effect of PDGFs/PDGFRs signaling pathway on the myocardial fibrosis in DOCA/salt hypertensive rats and its influence on cardiac fibroblasts and myofibroblasts.Methods Six
会议
Hemodynamic and electrocardiographic studies on pressure overload model in rats
Background Heart failure is the end-stage of various heart diseases.To have a better understand the mechanisms of heart failure,the pressure overload model in rats was built by abdominal transverse ao
会议
The effect of body fat distribution on insulin resistance and essential hypertension in non-diabetic
Background Fat is closely related to insulin resistance (IR) and hypertension.This article is to compare the effect of waist circumference (WC),hip circumstance (HC),epicardial fat volume (EFV) and bo
会议
Atorvastatin inhibits myocardial cell apoptosis induced by AngⅡ by reducing ER stress response
Background To determine the protective effect of atorvastatin on myocardial cells and to investigate the underlying mechanism of atorvastatin-mediated myocardium protection.Methods Newbom female rats
会议
Atorvastatin improves heart function of a rat model with post-myocardial infarction heart failure by
Background To determine the effect of atorvastatin on rat heart failure after myocardial infarction and to investigate the underlying mechanism of atorvastatin-mediated myocardium protection.Methods T
会议
Lack of association between PON1 gene polymorphisms and high platelet reactivity in patients undergo
Background There is a wide variation in the clinical therapeutic activity of clopidogrel,which has mainly been attributed to genetic effects.Recent a study reported that Paraoxonase-1 (PON1) as a key
会议