利用光响应的超分子远程开关构建智能谷胱甘肽硫转移酶

来源 :中国化学会第十届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户:jiemei2007126
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  酶活力在生物体内受到严格的反馈循环调控。受自然启发,人工设计可开关催化剂来精确控制生化反应吸引了科学家们的广泛兴趣。刺激响应型基团如偶氮苯、螺吡喃等都已被引入到智能催化剂的开发中来[1],而超分子体系以其较好的可逆性和刺激响应特性近年来成为重要的研究工具,例如Leigh等利用轮烷系统构建了多个调控催化系统[2],Brunsvele等利用CB[8]的主客体复合作用构建可开关调控的荧火素酶[3]。
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