Hepatocellular carcinoma(HCC)is the worlds 3rd leading cause of cancer-related deaths.83%of patients die within 5 years,and it is now one of the fastest growing cancers in the US.Early detection of HCC is critical for the effective treatment.Alpha fetoprotein(AFP)serum level is currently used for HCC screening,but the cutoff of the AFP test has limited sensitivity(about 50%),indicating a high false negative rate.