【摘 要】
：
Cytotoxic T lymphocyte (CTL) and natural killer (NK) cells are essential anti-tumor effector cells.The activity of these cells are regulated by a repertoire of
【机 构】
：
InstituteofImmunologySchoolofLifeSciencesandMedicalCenterTheKeyLaboratoryofInnateImmunityandChronicD
论文部分内容阅读
Cytotoxic T lymphocyte (CTL) and natural killer (NK) cells are essential anti-tumor effector cells.The activity of these cells are regulated by a repertoire of co-signaling (either co-stimulatory or co-inhibitory) cell-surface receptors that recognize their respective ligand (s) on tumor cells.In order to further harness the effector function of anti-tumor T cells, the checkpoint treatments, such as those using anti-CTLA-4 and/or anti-PD-1 mAb, are clinically proved to be efficient.However, as for current strategies basically limited to T cells, the therapeutic potential of activating anti-tumor NK cells by blocking co-inhibitory receptors on NK cells has seldom been investigated.
其他文献
Microglia, the resident immune cells of the spinal cord, become activated in response to peripheral nerve injury.Microglia activation contributes to the dev
γδ T-cells exert potent cytotoxicity against many solid tumors and haematological malignancies.In the case of human Vγ9Vδ2 T-cells, it is the CD277/BTN3-dep
Objective: Human T lymphocytes, bearing T-cell receptor (TCR) γδ, play an important role in tumor immunosurveillance and anti-tumor immune responses.
Animal models have provided important fundamental insights into biological and immunological processes that are common between species.However, many aspects of