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  5. Genetic screen to identify genes involved in maintaining lysosome morphology, function and dynamics

Genetic screen to identify genes involved in maintaining lysosome morphology, function and dynamics

来源 :The 7th International Symposium on Autophagy 2015(第七届自噬国际研讨会 | 被引量 : 0次 | 上传用户：nieyuhan
【摘 要】
：
Lysosomes are membrane-bound acidic organelles that degrade cargoes derived from endocytosis, phagocytosis or autophagy through the action of a variety of lysosomal hydrolases.The degradation products
【作 者】
：
Yuan Li Yubing Liu Yanan Sun Wei Zou Baohui Chen Xiaochen Wang 
【机 构】
：
National Institute of Biological Sciences, No.7 Science Park Road, Zhongguancun Life Science Park, B
【出 处】
：
The 7th International Symposium on Autophagy 2015(第七届自噬国际研讨会
【发表日期】
：
2015年9期
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Lysosomes are membrane-bound acidic organelles that degrade cargoes derived from endocytosis, phagocytosis or autophagy through the action of a variety of lysosomal hydrolases.The degradation products are exported from lysosomes by membrane transporters for the reutilization in cellular metabolism.Defects in either lysosomal hydrolytic enzymes or exports of hydrolysis products lead to inherited lysosomal storage disorders, indicating the importance of lysosomes in cellular homeostasis.
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